Interaction Of Immune Response Mediator Genes In A Predisposition To Juvenile Idiopathic Arthritis

Background/objective — The goal of our study was to investigate the role interaction between polymorphic loci immune response mediator genes (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, and PADI4 rs2240336) in formation a genetic predisposition juvenile idiopathic arthritis (JIA). Material Methods involved 330 JIA patients 342 volunteers from Republic Bashkortostan. Genotyping conducted via real-time polymerase chain reaction. gene-gene interactions were studied using multifactor dimensionality reduction algorithm. Results In general analysis, best model combination rs16944 – rs1800872 rs28362491 rs2240336 loci. However, after gender-based stratification results obtained when examining combinations rs1800795 girls rs2104286 boys. Within all these models, genotype associated with both augmented reduced risks identified (taking into account gender-specific differences). Conclusion implied that an important is played by